Cargando…
Highly homologous proteins exert opposite biological activities by using different interaction interfaces
We present a possible molecular basis for the opposite activity of two homologues proteins that bind similar ligands and show that this is achieved by fine-tuning of the interaction interface. The highly homologous ASPP proteins have opposite roles in regulating apoptosis: ASPP2 induces apoptosis wh...
Autores principales: | Iosub Amir, Anat, van Rosmalen, Martijn, Mayer, Guy, Lebendiker, Mario, Danieli, Tsafi, Friedler, Assaf |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4486954/ https://www.ncbi.nlm.nih.gov/pubmed/26130271 http://dx.doi.org/10.1038/srep11629 |
Ejemplares similares
-
The Trip Adviser guide to the protein science world: a proposal to improve the awareness concerning the quality of recombinant proteins
por: Lebendiker, Mario, et al.
Publicado: (2014) -
Thrombospondin-1-N-Terminal Domain Induces a Phagocytic State and Thrombospondin-1-C-Terminal Domain Induces a Tolerizing Phenotype in Dendritic Cells
por: Tabib, Adi, et al.
Publicado: (2009) -
The anti-apoptotic proteins NAF-1 and iASPP interact to drive apoptosis in cancer cells
por: Iosub-Amir, Anat, et al.
Publicado: (2018) -
Coupling Multi Angle Light Scattering to Ion Exchange chromatography (IEX-MALS) for protein characterization
por: Amartely, Hadar, et al.
Publicado: (2018) -
Publisher Correction: Coupling Multi Angle Light Scattering to Ion Exchange chromatography (IEX-MALS) for protein characterization
por: Amartely, Hadar, et al.
Publicado: (2019)