Transgenic sickle cell disease mice have high mortality and dysregulated immune responses after vaccination

BACKGROUND: Children with sickle cell disease (SCD) are susceptible to recurrent infections, which are often life threatening and necessitate frequent vaccinations. Given the altered baseline immunity and proinflammatory state associated with SCD, we sought to determine the relative safety and effic...

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Detalles Bibliográficos
Autores principales: Szczepanek, Steven M., Secor, Eric R., Bracken, Sonali J., Guernsey, Linda, Rafti, Ektor, Matson, Adam, Thrall, Roger S., Andemariam, Biree
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4487511/
https://www.ncbi.nlm.nih.gov/pubmed/23728384
http://dx.doi.org/10.1038/pr.2013.85

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4487511/
https://www.ncbi.nlm.nih.gov/pubmed/23728384
http://dx.doi.org/10.1038/pr.2013.85

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