Identification of a Dynamic Core Transcriptional Network in t(8;21) AML that Regulates Differentiation Block and Self-Renewal

Oncogenic transcription factors such as RUNX1/ETO, which is generated by the chromosomal translocation t(8;21), subvert normal blood cell development by impairing differentiation and driving malignant self-renewal. Here, we use digital footprinting and chromatin immunoprecipitation sequencing (ChIP-...

Descripción completa

Detalles Bibliográficos
Autores principales: Ptasinska, Anetta, Assi, Salam A., Martinez-Soria, Natalia, Imperato, Maria Rosaria, Piper, Jason, Cauchy, Pierre, Pickin, Anna, James, Sally R., Hoogenkamp, Maarten, Williamson, Dan, Wu, Mengchu, Tenen, Daniel G., Ott, Sascha, Westhead, David R., Cockerill, Peter N., Heidenreich, Olaf, Bonifer, Constanze
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4487811/
https://www.ncbi.nlm.nih.gov/pubmed/25242324
http://dx.doi.org/10.1016/j.celrep.2014.08.024

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4487811/
https://www.ncbi.nlm.nih.gov/pubmed/25242324
http://dx.doi.org/10.1016/j.celrep.2014.08.024

Ejemplares similares