Structure-Based Optimization and Biological Evaluation of Pancreatic Lipase Inhibitors as Novel Potential Antiobesity Agents

The unusual fused β-lactone vibralactone was isolated from cultures of the basidiomycete Boreostereum vibrans and has been shown to significantly inhibit pancreatic lipase. In this study, a structure-based lead optimization of vibralactone resulted in three series of 104 analogs, among which compoun...

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Detalles Bibliográficos
Autores principales: Wei, Kun, Wang, Gang-Qiang, Bai, Xue, Niu, Yan-Fen, Chen, He-Ping, Wen, Chun-Nan, Li, Zheng-Hui, Dong, Ze-Jun, Zuo, Zhi-Li, Xiong, Wen-Yong, Liu, Ji-Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488150/
https://www.ncbi.nlm.nih.gov/pubmed/26085282
http://dx.doi.org/10.1007/s13659-015-0062-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488150/
https://www.ncbi.nlm.nih.gov/pubmed/26085282
http://dx.doi.org/10.1007/s13659-015-0062-6

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