Channel Activity of Cardiac Ryanodine Receptors (RyR2) Determines Potency and Efficacy of Flecainide and R-Propafenone against Arrhythmogenic Calcium Waves in Ventricular Cardiomyocytes

Flecainide blocks ryanodine receptor type 2 (RyR2) channels in the open state, suppresses arrhythmogenic Ca(2+) waves and prevents catecholaminergic polymorphic ventricular tachycardia (CPVT) in mice and humans. We hypothesized that differences in RyR2 activity induced by CPVT mutations determines t...

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Detalles Bibliográficos
Autores principales: Savio-Galimberti, Eleonora, Knollmann, Björn C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488248/
https://www.ncbi.nlm.nih.gov/pubmed/26121139
http://dx.doi.org/10.1371/journal.pone.0131179

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488248/
https://www.ncbi.nlm.nih.gov/pubmed/26121139
http://dx.doi.org/10.1371/journal.pone.0131179

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