Inactivation of p53 Is Sufficient to Induce Development of Pulmonary Hypertension in Rats

OBJECTIVE: Pulmonary artery smooth muscle cells (PA-SMCs) in pulmonary arterial hypertension (PAH) show similarities to cancer cells. Due to the growth-suppressive and pro-apoptotic effects of p53 and its inactivation in cancer, we hypothesized that the p53 pathway could be altered in PAH. We theref...

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Detalles Bibliográficos
Autores principales: Jacquin, S., Rincheval, V., Mignotte, B., Richard, S., Humbert, M., Mercier, O., Londoño-Vallejo, A., Fadel, E., Eddahibi, S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488287/
https://www.ncbi.nlm.nih.gov/pubmed/26121334
http://dx.doi.org/10.1371/journal.pone.0131940

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488287/
https://www.ncbi.nlm.nih.gov/pubmed/26121334
http://dx.doi.org/10.1371/journal.pone.0131940

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