Cargando…

Inactivation of p53 Is Sufficient to Induce Development of Pulmonary Hypertension in Rats

OBJECTIVE: Pulmonary artery smooth muscle cells (PA-SMCs) in pulmonary arterial hypertension (PAH) show similarities to cancer cells. Due to the growth-suppressive and pro-apoptotic effects of p53 and its inactivation in cancer, we hypothesized that the p53 pathway could be altered in PAH. We theref...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jacquin, S., Rincheval, V., Mignotte, B., Richard, S., Humbert, M., Mercier, O., Londoño-Vallejo, A., Fadel, E., Eddahibi, S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488287/ https://www.ncbi.nlm.nih.gov/pubmed/26121334 http://dx.doi.org/10.1371/journal.pone.0131940

Ejemplares similares

Smooth Muscle Phenotype in Idiopathic Pulmonary Hypertension: Hyper-Proliferative but not Cancerous
por: Perros, Frédéric, et al.
Publicado: (2019)

The Beneficial Effect of Suramin on Monocrotaline-Induced Pulmonary Hypertension in Rats
por: Izikki, Mohamed, et al.
Publicado: (2013)

Key Role of the Endothelial TGF-β/ALK1/Endoglin Signaling Pathway in Humans and Rodents Pulmonary Hypertension
por: Gore, Benoît, et al.
Publicado: (2014)

Pulmonary endothelial cell DNA methylation signature in pulmonary arterial hypertension
por: Hautefort, Aurélie, et al.
Publicado: (2017)

Acute decompensated pulmonary hypertension
por: Savale, Laurent, et al.
Publicado: (2017)

Anorexigen-induced pulmonary hypertension and the serotonin (5-HT) hypothesis: lessons for the future in pathogenesis
por: Eddahibi, Saadia, et al.
Publicado: (2002)

Endothelial cell apoptosis in chronically obstructed and reperfused pulmonary artery
por: Sage, Edouard, et al.
Publicado: (2008)

Description, Staging and Quantification of Pulmonary Artery Angiophagy in a Large Animal Model of Chronic Thromboembolic Pulmonary Hypertension
por: Perros, Frédéric, et al.
Publicado: (2020)

Partial p53 reactivation is sufficient to induce cancer regression
por: Klimovich, Boris, et al.
Publicado: (2022)

French experience of balloon pulmonary angioplasty for chronic thromboembolic pulmonary hypertension
por: Brenot, Philippe, et al.
Publicado: (2019)

Pulsatile pulmonary artery pressure in a large animal model of chronic thromboembolic pulmonary hypertension: Similarities and differences with human data
por: Boulate, David, et al.
Publicado: (2022)

Mutating RBF Can Enhance Its Pro-Apoptotic Activity and Uncovers a New Role in Tissue Homeostasis
por: Milet, Cécile, et al.
Publicado: (2014)

Impact of interleukin-6 on hypoxia-induced pulmonary hypertension and lung inflammation in mice
por: Savale, Laurent, et al.
Publicado: (2009)

HPV infection and p53 inactivation in pterygium
por: Tsai, Yi-Yu, et al.
Publicado: (2009)

The pro-apoptotic activity of Drosophila Rbf1 involves dE2F2-dependent downregulation of diap1 and buffy mRNA
por: Clavier, A, et al.
Publicado: (2014)

Increased oxidative stress and severe arterial remodeling induced by permanent high-flow challenge in experimental pulmonary hypertension
por: Dorfmüller, Peter, et al.
Publicado: (2011)

Cas9 activates the p53 pathway and selects for p53-inactivating mutations
por: Enache, Oana M., et al.
Publicado: (2020)

Pulmonary Hypertension Complicating Fibrosing Mediastinitis
por: Seferian, Andrei, et al.
Publicado: (2015)

Th2 CD4(+) T Cells Are Necessary and Sufficient for Schistosoma‐Pulmonary Hypertension
por: Kumar, Rahul, et al.
Publicado: (2019)

Role of smooth muscle cell p53 in pulmonary arterial hypertension
por: Wakasugi, Takayuki, et al.
Publicado: (2019)

Echocardiographic evaluations of right ventriculo–arterial coupling in experimental and clinical pulmonary hypertension
por: Boulate, David, et al.
Publicado: (2019)

The role of p53 inactivation in human cervical cell carcinoma development.
por: Miwa, K., et al.
Publicado: (1995)

VHL inactivation without hypoxia is sufficient to achieve genome hypermethylation
por: Artemov, Artem V., et al.
Publicado: (2018)

Spontaneous inactivating p53 mutations and the “selfish cell”
por: Sorscher, Steven M., et al.
Publicado: (2011)

High-SETD8 inactivates p53 in neuroblastoma
por: Veschi, Veronica, et al.
Publicado: (2017)

Antitumor mechanisms when pRb and p53 are genetically inactivated
por: Zhu, Liang, et al.
Publicado: (2014)

The Long March to a Cure for Pulmonary Hypertension
por: Humbert, Marc
Publicado: (2022)

Right Ventricle Remodeling Metabolic Signature in Experimental Pulmonary Hypertension Models of Chronic Hypoxia and Monocrotaline Exposure
por: Hautbergue, Thaïs, et al.
Publicado: (2021)

Risk assessment in pulmonary arterial hypertension
por: Raina, Amresh, et al.
Publicado: (2016)

Illuminating the Importance of Pulmonary Arterial Compliance in Pulmonary Hypertension
por: Weatherald, Jason, et al.
Publicado: (2023)

Reversible inactivation of the transcriptional function of P53 protein by farnesylation
por: Couderc, Bettina, et al.
Publicado: (2006)

Inactivation of p53 gene in human and murine osteosarcoma cells.
por: Chandar, N., et al.
Publicado: (1992)

Dietary Supplementation with Silicon-Enriched Spirulina Improves Arterial Remodeling and Function in Hypertensive Rats
por: Arthur-Ataam, Joanna, et al.
Publicado: (2019)

Heterozygous inactivation of tsc2 enhances tumorigenesis in p53 mutant zebrafish
por: Kim, Seok-Hyung, et al.
Publicado: (2013)

Effects of bone marrow-derived cells on monocrotaline- and hypoxia-induced pulmonary hypertension in mice
por: Raoul, William, et al.
Publicado: (2007)

Current Knowledge and Recent Advances of Right Ventricular Molecular Biology and Metabolism from Congenital Heart Disease to Chronic Pulmonary Hypertension
por: Guimaron, Samantha, et al.
Publicado: (2018)

Screening strategies for pulmonary arterial hypertension
por: Kiely, David G, et al.
Publicado: (2019)

Hemodynamic trajectories and outcomes in patients with pulmonary arterial hypertension
por: Amsallem, Myriam, et al.
Publicado: (2020)

Loss of LZAP inactivates p53 and regulates sensitivity of cells to DNA damage in a p53-dependent manner
por: Wamsley, J J, et al.
Publicado: (2017)

Stabilization and Localization of Xist RNA are Controlled by Separate Mechanisms and are Not Sufficient for X Inactivation
por: Clemson, Christine Moulton, et al.
Publicado: (1998)

Cannot write session to /tmp/vufind_sessions/sess_guv9qp8f9k83auk5k5p17d6jr0