Sortase Enzyme-Mediated Generation of Site-Specifically Conjugated Antibody Drug Conjugates with High In Vitro and In Vivo Potency

Antibody drug conjugates (ADCs) have recently been proven to be highly potent anti-tumor drugs, typically exceeding the efficacy of conventional monoclonal antibodies (mAbs). ADCs are currently produced by chemical conjugation of a small-molecule toxin to the mAb through lysine or cysteine side chai...

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Detalles Bibliográficos
Autores principales: Beerli, Roger R., Hell, Tamara, Merkel, Anna S., Grawunder, Ulf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488448/
https://www.ncbi.nlm.nih.gov/pubmed/26132162
http://dx.doi.org/10.1371/journal.pone.0131177

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488448/
https://www.ncbi.nlm.nih.gov/pubmed/26132162
http://dx.doi.org/10.1371/journal.pone.0131177

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