The Effect of Rifampin on the Pharmacokinetics of Edoxaban in Healthy Adults

BACKGROUND AND OBJECTIVE: The oral direct factor Xa inhibitor edoxaban is a P-glycoprotein (P-gp) substrate metabolized via carboxylesterase-1 and cytochrome P450 (CYP) 3A4/5. The effect of rifampin-induced induction of P-gp and CYP3A4/5 on transport and metabolism of edoxaban through the CYP3A4/5 p...

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Detalles Bibliográficos
Autores principales: Mendell, Jeanne, Chen, Shuquan, He, Ling, Desai, Madhuri, Parasramupria, Dolly A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2015
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488474/
https://www.ncbi.nlm.nih.gov/pubmed/26068927
http://dx.doi.org/10.1007/s40261-015-0298-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488474/
https://www.ncbi.nlm.nih.gov/pubmed/26068927
http://dx.doi.org/10.1007/s40261-015-0298-2

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