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The Effect of Rifampin on the Pharmacokinetics of Edoxaban in Healthy Adults

BACKGROUND AND OBJECTIVE: The oral direct factor Xa inhibitor edoxaban is a P-glycoprotein (P-gp) substrate metabolized via carboxylesterase-1 and cytochrome P450 (CYP) 3A4/5. The effect of rifampin-induced induction of P-gp and CYP3A4/5 on transport and metabolism of edoxaban through the CYP3A4/5 p...

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Detalles Bibliográficos
Autores principales:	Mendell, Jeanne, Chen, Shuquan, He, Ling, Desai, Madhuri, Parasramupria, Dolly A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2015
Materias:	Original Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488474/ https://www.ncbi.nlm.nih.gov/pubmed/26068927 http://dx.doi.org/10.1007/s40261-015-0298-2

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