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An Inactive Geminin Mutant That Binds Cdt1

The initiation of DNA replication is tightly regulated in order to ensure that the genome duplicates only once per cell cycle. In vertebrate cells, the unstable regulatory protein Geminin prevents a second round of DNA replication by inhibiting the essential replication factor Cdt1. Cdt1 recruits mi...

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Detalles Bibliográficos
Autores principales: Suchyta, Marissa, Miotto, Benoit, McGarry, Thomas J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488664/
https://www.ncbi.nlm.nih.gov/pubmed/25988259
http://dx.doi.org/10.3390/genes6020252