Inhibition of P-glycoprotein Gene Expression and Function Enhances Triptolide-induced Hepatotoxicity in Mice

Triptolide (TP) is the major active principle of Tripterygium wilfordii Hook f. and very effective in treatment of autoimmune diseases. However, TP induced hepatotoxicity limited its clinical applications. Our previous study found that TP was a substrate of P-glycoprotein and its hepatobiliary clear...

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Detalles Bibliográficos
Autores principales: Kong, Ling-Lei, zhuang, Xiao-Mei, Yang, Hai-Ying, Yuan, Mei, Xu, Liang, Li, Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488747/
https://www.ncbi.nlm.nih.gov/pubmed/26134275
http://dx.doi.org/10.1038/srep11747

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488747/
https://www.ncbi.nlm.nih.gov/pubmed/26134275
http://dx.doi.org/10.1038/srep11747

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