6-Mercaptopurine reduces cytokine and Muc5ac expression involving inhibition of NFκB activation in airway epithelial cells

BACKGROUND: Mucus hypersecretion and excessive cytokine synthesis is associated with many of the pathologic features of chronic airway diseases such as asthma. 6-Mercaptopurine (6-MP) is an immunosuppressive drug that is widely used in several inflammatory disorders. Although 6-MP has been used to t...

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Detalles Bibliográficos
Autores principales: Kurakula, Kondababu, Hamers, Anouk A., van Loenen, Pieter, de Vries, Carlie J.M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489194/
https://www.ncbi.nlm.nih.gov/pubmed/26084512
http://dx.doi.org/10.1186/s12931-015-0236-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489194/
https://www.ncbi.nlm.nih.gov/pubmed/26084512
http://dx.doi.org/10.1186/s12931-015-0236-0

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