Rigidity Emerges during Antibody Evolution in Three Distinct Antibody Systems: Evidence from QSFR Analysis of Fab Fragments

The effects of somatic mutations that transform polyspecific germline (GL) antibodies to affinity mature (AM) antibodies with monospecificity are compared among three GL-AM Fab pairs. In particular, changes in conformational flexibility are assessed using a Distance Constraint Model (DCM). We have p...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Tong, Tracka, Malgorzata B., Uddin, Shahid, Casas-Finet, Jose, Jacobs, Donald J., Livesay, Dennis R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489365/
https://www.ncbi.nlm.nih.gov/pubmed/26132144
http://dx.doi.org/10.1371/journal.pcbi.1004327

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489365/
https://www.ncbi.nlm.nih.gov/pubmed/26132144
http://dx.doi.org/10.1371/journal.pcbi.1004327

Ejemplares similares