Conditional Deletion of TAK1 in T Cells Reveals a Pivotal Role of TCRαβ(+) Intraepithelial Lymphocytes in Preventing Lymphopenia-Associated Colitis

The kinase TAK is required for the development of conventional and regulatory T cells. We previously reported that mice with conditional deletion of TAK1 in T cells (Lck-cre:TAK1(fl/fl) mice) exhibited severe T lymphopenia, and were nevertheless predisposed to spontaneous colitis with unknown etiolo...

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Detalles Bibliográficos
Autores principales: Sanjo, Hideki, Tokumaru, Shigeo, Akira, Shizuo, Taki, Shinsuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489433/
https://www.ncbi.nlm.nih.gov/pubmed/26132627
http://dx.doi.org/10.1371/journal.pone.0128761

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489433/
https://www.ncbi.nlm.nih.gov/pubmed/26132627
http://dx.doi.org/10.1371/journal.pone.0128761

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