Phenylbutyrate Is Bacteriostatic against Mycobacterium tuberculosis and Regulates the Macrophage Response to Infection, Synergistically with 25-Hydroxy-Vitamin D₃

Adjunctive vitamin D treatment for pulmonary tuberculosis enhances resolution of inflammation but has modest effects on bacterial clearance. Sodium 4-phenylbutyrate (PBA) is in clinical use for a range of conditions and has been shown to synergise with vitamin D metabolites to upregulate cathelicidi...

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Detalles Bibliográficos
Autores principales: Coussens, Anna K., Wilkinson, Robert J., Martineau, Adrian R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489717/
https://www.ncbi.nlm.nih.gov/pubmed/26133770
http://dx.doi.org/10.1371/journal.ppat.1005007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489717/
https://www.ncbi.nlm.nih.gov/pubmed/26133770
http://dx.doi.org/10.1371/journal.ppat.1005007

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