Vitamin D Antagonises the Suppressive Effect of Inflammatory Cytokines on CTLA-4 Expression and Regulatory Function

The immune suppressive protein CTLA-4 is constitutively expressed by Tregs and induced in effector T cells upon activation. Its crucial role in adaptive immunity is apparent from the fatal autoimmune pathology seen in CTLA-4 knockout mice. However, little is known regarding factors that regulate CTL...

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Detalles Bibliográficos
Autores principales: Jeffery, Louisa E., Qureshi, Omar S., Gardner, David, Hou, Tie Z., Briggs, Zoe, Soskic, Blagoje, Baker, Jennifer, Raza, Karim, Sansom, David M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489761/
https://www.ncbi.nlm.nih.gov/pubmed/26134669
http://dx.doi.org/10.1371/journal.pone.0131539

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489761/
https://www.ncbi.nlm.nih.gov/pubmed/26134669
http://dx.doi.org/10.1371/journal.pone.0131539

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