Hydroxychloroquine Destabilizes Phospho-S6 in Human Renal Carcinoma Cells

mTOR inhibitors are used to treat metastatic renal cell cancer (RCC), but most patients eventually become resistant. One possible mechanism for resistance is upregulation of autophagy, a pathway that helps recycle intracellular proteins and promotes cell survival. Hydroxychloroquine (HCQ), a potent...

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Detalles Bibliográficos
Autores principales: Lee, Hyung-Ok, Mustafa, Aladdin, Hudes, Gary R., Kruger, Warren D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489871/
https://www.ncbi.nlm.nih.gov/pubmed/26134285
http://dx.doi.org/10.1371/journal.pone.0131464

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489871/
https://www.ncbi.nlm.nih.gov/pubmed/26134285
http://dx.doi.org/10.1371/journal.pone.0131464

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