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Hydroxychloroquine Destabilizes Phospho-S6 in Human Renal Carcinoma Cells
mTOR inhibitors are used to treat metastatic renal cell cancer (RCC), but most patients eventually become resistant. One possible mechanism for resistance is upregulation of autophagy, a pathway that helps recycle intracellular proteins and promotes cell survival. Hydroxychloroquine (HCQ), a potent...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489871/ https://www.ncbi.nlm.nih.gov/pubmed/26134285 http://dx.doi.org/10.1371/journal.pone.0131464 |