SAMHD1 Inhibits LINE-1 Retrotransposition by Promoting Stress Granule Formation

The SAM domain and HD domain containing protein 1 (SAMHD1) inhibits retroviruses, DNA viruses and long interspersed element 1 (LINE-1). Given that in dividing cells, SAMHD1 loses its antiviral function yet still potently restricts LINE-1, we propose that, instead of blocking viral DNA synthesis by v...

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Detalles Bibliográficos
Autores principales: Hu, Siqi, Li, Jian, Xu, Fengwen, Mei, Shan, Le Duff, Yann, Yin, Lijuan, Pang, Xiaojing, Cen, Shan, Jin, Qi, Liang, Chen, Guo, Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489885/
https://www.ncbi.nlm.nih.gov/pubmed/26134849
http://dx.doi.org/10.1371/journal.pgen.1005367

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489885/
https://www.ncbi.nlm.nih.gov/pubmed/26134849
http://dx.doi.org/10.1371/journal.pgen.1005367

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