Cargando…

SAMHD1 Inhibits LINE-1 Retrotransposition by Promoting Stress Granule Formation

The SAM domain and HD domain containing protein 1 (SAMHD1) inhibits retroviruses, DNA viruses and long interspersed element 1 (LINE-1). Given that in dividing cells, SAMHD1 loses its antiviral function yet still potently restricts LINE-1, we propose that, instead of blocking viral DNA synthesis by v...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hu, Siqi, Li, Jian, Xu, Fengwen, Mei, Shan, Le Duff, Yann, Yin, Lijuan, Pang, Xiaojing, Cen, Shan, Jin, Qi, Liang, Chen, Guo, Fei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489885/ https://www.ncbi.nlm.nih.gov/pubmed/26134849 http://dx.doi.org/10.1371/journal.pgen.1005367

Ejemplares similares

Modulation of LINE-1 and Alu/SVA Retrotransposition by Aicardi-Goutières Syndrome-Related SAMHD1
por: Zhao, Ke, et al.
Publicado: (2013)

MxB inhibits long interspersed element type 1 retrotransposition
por: Huang, Yu, et al.
Publicado: (2022)

Schlafen-5 inhibits LINE-1 retrotransposition
por: Ding, Jiwei, et al.
Publicado: (2023)

Identification of novel key amino acids at the interface of the transmembrane domains of human BST-2 and HIV-1 Vpu
por: Pang, Xiaojing, et al.
Publicado: (2013)

The Zinc-Finger protein ZCCHC3 inhibits LINE-1 retrotransposition
por: Zhang, Zixiong, et al.
Publicado: (2022)

Inhibition of LINE-1 Retrotransposition by Capsaicin
por: Nishikawa, Yuki, et al.
Publicado: (2018)

Condensation of LINE-1 is critical for retrotransposition
por: Sil, Srinjoy, et al.
Publicado: (2023)

ZCCHC3 is a stress granule zinc knuckle protein that strongly suppresses LINE-1 retrotransposition
por: Goodier, John L., et al.
Publicado: (2023)

ADAR1 restricts LINE-1 retrotransposition
por: Orecchini, Elisa, et al.
Publicado: (2017)

Interferon-inducible SAMHD1 restricts viral replication through downregulation of lipid synthesis
por: An, Ni, et al.
Publicado: (2022)

HIV-1 infection induces retrotransposition of LINE-1 elements
por: Jones, R Brad, et al.
Publicado: (2009)

Identification of the 'basal' human LINE-1 retrotransposition complex
por: Doucet, Aurélien J, et al.
Publicado: (2009)

LINE-1 and Alu retrotransposition exhibit clonal variation
por: Streva, Vincent A, et al.
Publicado: (2013)

Heavy Metals Stimulate Human LINE-1 Retrotransposition
por: Kale, Shubha P., et al.
Publicado: (2005)

Tumor suppressor proteins restricts LINE-1 retrotransposition
por: Kuroki, Misao, et al.
Publicado: (2013)

Engineered LINE-1 retrotransposition in nondividing human neurons
por: Macia, Angela, et al.
Publicado: (2017)

Poxviruses capture host genes by LINE-1 retrotransposition
por: Fixsen, Sarah M, et al.
Publicado: (2022)

Crossing the LINE Toward Genomic Instability: LINE-1 Retrotransposition in Cancer
por: Kemp, Jacqueline R., et al.
Publicado: (2015)

CRISPR-Cas13a Inhibits HIV-1 Infection
por: Yin, Lijuan, et al.
Publicado: (2020)

The SAMHD1-mediated block of LINE-1 retroelements is regulated by phosphorylation
por: Herrmann, Alexandra, et al.
Publicado: (2018)

Substrates and Inhibitors of SAMHD1
por: Hollenbaugh, Joseph A., et al.
Publicado: (2017)

Correction to: The SAMHD1-mediated block of LINE-1 retroelements is regulated by phosphorylation
por: Herrmann, A., et al.
Publicado: (2018)

Truncated ORF1 proteins can suppress LINE-1 retrotransposition in trans
por: Sokolowski, Mark, et al.
Publicado: (2017)

SAMHD1 Mutations and Expression in Mantle Cell Lymphoma Patients
por: Wang, Tao, et al.
Publicado: (2021)

LINE-1 Retrotransposition: Impact on Genome Stability and Diversity and Human Disease
por: Prak, Nina Luning, et al.
Publicado: (2006)

The Flow of the Gibbon LAVA Element Is Facilitated by the LINE-1 Retrotransposition Machinery
por: Meyer, Thomas J., et al.
Publicado: (2016)

Uridylation by TUT4/7 Restricts Retrotransposition of Human LINE-1s
por: Warkocki, Zbigniew, et al.
Publicado: (2018)

Deamination-independent restriction of LINE-1 retrotransposition by APOBEC3H
por: Feng, Yuqing, et al.
Publicado: (2017)

Promoter methylation, transcription, and retrotransposition of LINE-1 in colorectal adenomas and adenocarcinomas
por: Shademan, Milad, et al.
Publicado: (2020)

Sequestration of LINE‐1 in cytosolic aggregates by MOV10 restricts retrotransposition
por: Arora, Rajika, et al.
Publicado: (2022)

Nef Suppresses LINE-1 Retrotransposition through Two Distinct Mechanisms
por: Wang, Yu, et al.
Publicado: (2022)

Differential inhibition of LINE1 and LINE2 retrotransposition by vertebrate AID/APOBEC proteins
por: Lindič, Nataša, et al.
Publicado: (2013)

Equine lentivirus counteracts SAMHD1 restriction by Rev-mediated degradation of SAMHD1 via the BECN1-dependent lysosomal pathway
por: Ren, Huiling, et al.
Publicado: (2020)

LINE retrotransposition and host DNA repair machinery
por: Yamaguchi, Katsumi, et al.
Publicado: (2015)

BST2 Suppresses LINE-1 Retrotransposition by Reducing the Promoter Activity of LINE-1 5′ UTR
por: Zhao, Yifei, et al.
Publicado: (2022)

Effect of reverse transcriptase inhibitors on LINE-1 and Ty1 reverse transcriptase activities and on LINE-1 retrotransposition
por: Dai, Lixin, et al.
Publicado: (2011)

Restriction of diverse retroviruses by SAMHD1
por: Gramberg, Thomas, et al.
Publicado: (2013)

SAMHD1 Functions and Human Diseases
por: Coggins, Si’Ana A., et al.
Publicado: (2020)

SAMHD1 … and Viral Ways around It
por: Deutschmann, Janina, et al.
Publicado: (2021)

SAMHD1 in cancer: curse or cure?
por: Schott, Kerstin, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_80a1gf7sk9e9m01numpsqdj46k