Dissecting the Mechanisms of Doxorubicin and Oxidative Stress-Induced Cytotoxicity: The Involvement of Actin Cytoskeleton and ROCK1

We have recently reported that ROCK1 deficiency in mouse embryonic fibroblasts (MEF) has superior anti-apoptotic and pro-survival effects than antioxidants against doxorubicin, a chemotherapeutic drug. Although oxidative stress is the most widely accepted mechanism, our studies suggest that ROCK1-de...

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Detalles Bibliográficos
Autores principales: Wei, Lei, Surma, Michelle, Gough, Gina, Shi, Stephanie, Lambert-Cheatham, Nathan, Chang, Jiang, Shi, Jianjian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489912/
https://www.ncbi.nlm.nih.gov/pubmed/26134406
http://dx.doi.org/10.1371/journal.pone.0131763

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489912/
https://www.ncbi.nlm.nih.gov/pubmed/26134406
http://dx.doi.org/10.1371/journal.pone.0131763

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