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Cytosolic extensions directly regulate a rhomboid protease by modulating substrate gating
Intramembrane proteases catalyze the signal-generating step of various cell signaling pathways, and continue to be implicated in diseases ranging from malaria infection to Parkinsonian neurodegeneration(1–3). Despite playing such decisive roles, it remains unclear whether or how these membrane-immer...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490020/ https://www.ncbi.nlm.nih.gov/pubmed/25970241 http://dx.doi.org/10.1038/nature14357 |