Programmed cell death 5 mediates HDAC3 decay to promote genotoxic stress response

The inhibition of p53 activity by histone deacetylase 3 (HDAC3) has been reported, but the precise molecular mechanism is unknown. Here we show that programmed cell death 5 (PDCD5) selectively mediates HDAC3 dissociation from p53, which induces HDAC3 cleavage and ubiquitin-dependent proteasomal degr...

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Detalles Bibliográficos
Autores principales: Choi, Hyo-Kyoung, Choi, Youngsok, Park, Eun Sung, Park, Soo-Yeon, Lee, Seung-Hyun, Seo, Jaesung, Jeong, Mi-Hyeon, Jeong, Jae-Wook, Jeong, Jae-Ho, Lee, Peter C. W., Choi, Kyung-Chul, Yoon, Ho-Geun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490383/
https://www.ncbi.nlm.nih.gov/pubmed/26077467
http://dx.doi.org/10.1038/ncomms8390

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490383/
https://www.ncbi.nlm.nih.gov/pubmed/26077467
http://dx.doi.org/10.1038/ncomms8390

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