Discovery of ODM-201, a new-generation androgen receptor inhibitor targeting resistance mechanisms to androgen signaling-directed prostate cancer therapies

Activation of androgen receptor (AR) is crucial for prostate cancer growth. Remarkably, also castration-resistant prostate cancer (CRPC) is dependent on functional AR, and several mechanisms have been proposed to explain the addiction. Known causes of CRPC include gene amplification and overexpressi...

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Detalles Bibliográficos
Autores principales: Moilanen, Anu-Maarit, Riikonen, Reetta, Oksala, Riikka, Ravanti, Laura, Aho, Eija, Wohlfahrt, Gerd, Nykänen, Pirjo S., Törmäkangas, Olli P., Palvimo, Jorma J., Kallio, Pekka J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490394/
https://www.ncbi.nlm.nih.gov/pubmed/26137992
http://dx.doi.org/10.1038/srep12007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490394/
https://www.ncbi.nlm.nih.gov/pubmed/26137992
http://dx.doi.org/10.1038/srep12007

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