Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation

β-Sheet-rich α-synuclein (αS) aggregates characterize Parkinson's disease (PD). αS was long believed to be a natively unfolded monomer, but recent work suggests it also occurs in α-helix-rich tetramers. Crosslinking traps principally tetrameric αS in intact normal neurons, but not after cell ly...

Descripción completa

Detalles Bibliográficos
Autores principales: Dettmer, Ulf, Newman, Andrew J., Soldner, Frank, Luth, Eric S., Kim, Nora C., von Saucken, Victoria E., Sanderson, John B., Jaenisch, Rudolf, Bartels, Tim, Selkoe, Dennis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490410/
https://www.ncbi.nlm.nih.gov/pubmed/26076669
http://dx.doi.org/10.1038/ncomms8314

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490410/
https://www.ncbi.nlm.nih.gov/pubmed/26076669
http://dx.doi.org/10.1038/ncomms8314

Ejemplares similares