Synthesis, DNA Binding, and Antiproliferative Activity of Novel Acridine-Thiosemicarbazone Derivatives

In this work, the acridine nucleus was used as a lead-compound for structural modification by adding different substituted thiosemicarbazide moieties. Eight new (Z)-2-(acridin-9-ylmethylene)-N-phenylhydrazinecarbothioamide derivatives (3a–h) were synthesized, their antiproliferative activities were...

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Detalles Bibliográficos
Autores principales: de Almeida, Sinara Mônica Vitalino, Lafayette, Elizabeth Almeida, Gomes da Silva, Lúcia Patrícia Bezerra, Amorim, Cézar Augusto da Cruz, de Oliveira, Tiago Bento, Gois Ruiz, Ana Lucia Tasca, de Carvalho, João Ernesto, de Moura, Ricardo Olímpio, Beltrão, Eduardo Isidoro Carneiro, de Lima, Maria do Carmo Alves, de Carvalho Júnior, Luiz Bezerra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490484/
https://www.ncbi.nlm.nih.gov/pubmed/26068233
http://dx.doi.org/10.3390/ijms160613023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490484/
https://www.ncbi.nlm.nih.gov/pubmed/26068233
http://dx.doi.org/10.3390/ijms160613023

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