Cdk1 phosphorylates the Rac activator Tiam1 to activate centrosomal Pak and promote mitotic spindle formation

Centrosome separation is critical for bipolar spindle formation and the accurate segregation of chromosomes during mammalian cell mitosis. Kinesin-5 (Eg5) is a microtubule motor essential for centrosome separation, and Tiam1 and its substrate Rac antagonize Eg5-dependent centrosome separation in ear...

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Detalles Bibliográficos
Autores principales: Whalley, Helen J., Porter, Andrew P., Diamantopoulou, Zoi, White, Gavin R. M., Castañeda-Saucedo, Eduardo, Malliri, Angeliki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490568/
https://www.ncbi.nlm.nih.gov/pubmed/26078008
http://dx.doi.org/10.1038/ncomms8437

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490568/
https://www.ncbi.nlm.nih.gov/pubmed/26078008
http://dx.doi.org/10.1038/ncomms8437

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