Cargando…

Cdk1 phosphorylates the Rac activator Tiam1 to activate centrosomal Pak and promote mitotic spindle formation

Centrosome separation is critical for bipolar spindle formation and the accurate segregation of chromosomes during mammalian cell mitosis. Kinesin-5 (Eg5) is a microtubule motor essential for centrosome separation, and Tiam1 and its substrate Rac antagonize Eg5-dependent centrosome separation in ear...

Descripción completa

Detalles Bibliográficos
Autores principales:	Whalley, Helen J., Porter, Andrew P., Diamantopoulou, Zoi, White, Gavin R. M., Castañeda-Saucedo, Eduardo, Malliri, Angeliki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Pub. Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490568/ https://www.ncbi.nlm.nih.gov/pubmed/26078008 http://dx.doi.org/10.1038/ncomms8437

Ejemplares similares

Tiam1-Rac Signaling Counteracts Eg5 during Bipolar Spindle Assembly to Facilitate Chromosome Congression
por: Woodcock, Simon A., et al.
Publicado: (2010)

The RAC1 activator Tiam1 regulates centriole duplication through controlling PLK4 levels
por: Porter, Andrew P., et al.
Publicado: (2021)

STEF/TIAM2-mediated Rac1 activity at the nuclear envelope regulates the perinuclear actin cap
por: Woroniuk, Anna, et al.
Publicado: (2018)

β2-syntrophin and Par-3 promote an apicobasal Rac activity gradient at cell-cell junctions by differentially regulating Tiam1 activity
por: Mack, Natalie A., et al.
Publicado: (2012)

HUWE1 Ubiquitylates and Degrades the RAC Activator TIAM1 Promoting Cell-Cell Adhesion Disassembly, Migration, and Invasion
por: Vaughan, Lynsey, et al.
Publicado: (2014)

The interaction between CASK and the tumour suppressor Dlg1 regulates mitotic spindle orientation in mammalian epithelia
por: Porter, Andrew P., et al.
Publicado: (2019)

Rac1 in human diseases: The therapeutic potential of targeting Rac1 signaling regulatory mechanisms
por: Marei, Hadir, et al.
Publicado: (2016)

TIAM1-RAC1 promote small-cell lung cancer cell survival through antagonizing Nur77-induced BCL2 conformational change
por: Payapilly, Aishwarya, et al.
Publicado: (2021)

GEFs: Dual regulation of Rac1 signaling
por: Marei, Hadir, et al.
Publicado: (2016)

A TIAM1-TRIM28 complex mediates epigenetic silencing of protocadherins to promote migration of lung cancer cells
por: Ginn, Lucy, et al.
Publicado: (2023)

The sirtuins promote Dishevelled-1 scaffolding of TIAM1, Rac activation, and cell migration
por: Saxena, Madhurima, et al.
Publicado: (2013)

Cyclin B1–Cdk1 Activation Continues after Centrosome Separation to Control Mitotic Progression
por: Lindqvist, Arne, et al.
Publicado: (2007)

Sinup is essential for the integrity of centrosomes and mitotic spindles in zebrafish embryos
por: Yoo, Kyeong-Won, et al.
Publicado: (2017)

TIAM1 Antagonizes TAZ/YAP Both in the Destruction Complex in the Cytoplasm and in the Nucleus to Inhibit Invasion of Intestinal Epithelial Cells
por: Diamantopoulou, Zoi, et al.
Publicado: (2017)

Integrin-linked kinase localizes to the centrosome and regulates mitotic spindle organization
por: Fielding, Andrew B., et al.
Publicado: (2008)

Mitotic Spindle Poles are Organized by Structural and Motor Proteins in Addition to Centrosomes
por: Gaglio, Tirso, et al.
Publicado: (1997)

Centrosomal Actin Assembly Is Required for Proper Mitotic Spindle Formation and Chromosome Congression
por: Plessner, Matthias, et al.
Publicado: (2019)

The Rac activator Tiam1 controls tight junction biogenesis in keratinocytes through binding to and activation of the Par polarity complex
por: Mertens, Alexander E.E., et al.
Publicado: (2005)

Tiam1/Rac1 complex controls Il17a transcription and autoimmunity
por: Kurdi, Ahmed T., et al.
Publicado: (2016)

The Rac activator Tiam1 is required for polarized protrusional outgrowth of primary astrocytes by affecting the organization of the microtubule network
por: Ellenbroek, Saskia I. J., et al.
Publicado: (2012)

AMBRA1 phosphorylation by CDK1 and PLK1 regulates mitotic spindle orientation
por: Faienza, Fiorella, et al.
Publicado: (2023)

Tiam1 interaction with the PAR complex promotes talin-mediated Rac1 activation during polarized cell migration
por: Wang, Shujie, et al.
Publicado: (2012)

Proteomic analysis of Rac1 signaling regulation by guanine nucleotide exchange factors
por: Marei, Hadir, et al.
Publicado: (2016)

Mitotic Acetylation of Microtubules Promotes Centrosomal PLK1 Recruitment and Is Required to Maintain Bipolar Spindle Homeostasis
por: Rasamizafy, Sylvia Fenosoa, et al.
Publicado: (2021)

Drosophila Xpd Regulates Cdk7 Localization, Mitotic Kinase Activity, Spindle Dynamics, and Chromosome Segregation
por: Li, Xiaoming, et al.
Publicado: (2010)

The phosphomimetic mutation of syndecan-4 binds and inhibits Tiam1 modulating Rac1 activity in PDZ interaction–dependent manner
por: Keller-Pinter, Aniko, et al.
Publicado: (2017)

Differential Rac1 signalling by guanine nucleotide exchange factors implicates FLII in regulating Rac1-driven cell migration
por: Marei, Hadir, et al.
Publicado: (2016)

CDK11(p58) Is Required for Centriole Duplication and Plk4 Recruitment to Mitotic Centrosomes
por: Franck, Nathalie, et al.
Publicado: (2011)

CDK5RAP2 functions in centrosome to spindle pole attachment and DNA damage response
por: Barr, Alexis R., et al.
Publicado: (2010)

Recruitment of Tiam1 to Semaphorin 4D Activates Rac and Enhances Proliferation, Invasion, and Metastasis in Oral Squamous Cell Carcinoma
por: Zhou, Hua, et al.
Publicado: (2016)

Mio depletion links mTOR regulation to Aurora A and Plk1 activation at mitotic centrosomes
por: Platani, Melpomeni, et al.
Publicado: (2015)

The Rac activator Tiam1 is required for α3β1-mediated laminin-5 deposition, cell spreading, and cell migration
por: Hamelers, Irene H.L., et al.
Publicado: (2005)

Phosphorylation of importin-α1 by CDK1–cyclin B1 controls mitotic spindle assembly
por: Guo, Li, et al.
Publicado: (2019)

Effect of PAK Inhibition on Cell Mechanics Depends on Rac1
por: Mierke, Claudia Tanja, et al.
Publicado: (2020)

Synergy between Multiple Microtubule-Generating Pathways Confers Robustness to Centrosome-Driven Mitotic Spindle Formation
por: Hayward, Daniel, et al.
Publicado: (2014)

Centrosome–nuclear axis repositioning drives the assembly of a bipolar spindle scaffold to ensure mitotic fidelity
por: Nunes, Vanessa, et al.
Publicado: (2020)

The APC/C targets the Cep152–Cep63 complex at the centrosome to regulate mitotic spindle assembly
por: Tischer, Thomas, et al.
Publicado: (2022)

Dendrite regeneration in C. elegans is controlled by the RAC GTPase CED-10 and the RhoGEF TIAM-1
por: Brar, Harjot Kaur, et al.
Publicado: (2022)

Ankyrin–Tiam1 Interaction Promotes Rac1 Signaling and Metastatic Breast Tumor Cell Invasion and Migration
por: Bourguignon, Lilly Y.W., et al.
Publicado: (2000)

Computational Prediction of Hot Spots and Binding Site of Inhibitor NSC23766 on Rac1 Binding With Tiam1
por: Zheng, Chunwen, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_76uu0r0e6ljl0a9ft2ouhp060e