4′-O-methylhonokiol increases levels of 2-arachidonoyl glycerol in mouse brain via selective inhibition of its COX-2-mediated oxygenation

BACKGROUND AND PURPOSE: 4′-O-methylhonokiol (MH) is a natural product showing anti-inflammatory, anti-osteoclastogenic, and neuroprotective effects. MH was reported to modulate cannabinoid CB2 receptors as an inverse agonist for cAMP production and an agonist for intracellular [Ca2+]. It was recentl...

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Detalles Bibliográficos
Autores principales: Chicca, Andrea, Gachet, Maria Salomé, Petrucci, Vanessa, Schuehly, Wolfgang, Charles, Roch-Philippe, Gertsch, Jürg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490613/
https://www.ncbi.nlm.nih.gov/pubmed/25962384
http://dx.doi.org/10.1186/s12974-015-0307-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490613/
https://www.ncbi.nlm.nih.gov/pubmed/25962384
http://dx.doi.org/10.1186/s12974-015-0307-7

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