Generation of aroE overexpression mutant of Bacillus megaterium for the production of shikimic acid

BACKGROUND: Shikimic acid, the sole chemical building block for the antiviral drug oseltamivir (Tamiflu®), is one of the potent pharmaceutical intermediates with three chiral centers. Here we report a metabolically engineered recombinant Bacillus megaterium strain with aroE (shikimate dehydrogenase)...

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Detalles Bibliográficos
Autores principales: Ghosh, Saptarshi, Banerjee, Uttam Chand
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490670/
https://www.ncbi.nlm.nih.gov/pubmed/25981549
http://dx.doi.org/10.1186/s12934-015-0251-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490670/
https://www.ncbi.nlm.nih.gov/pubmed/25981549
http://dx.doi.org/10.1186/s12934-015-0251-3

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