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Generation of aroE overexpression mutant of Bacillus megaterium for the production of shikimic acid
BACKGROUND: Shikimic acid, the sole chemical building block for the antiviral drug oseltamivir (Tamiflu®), is one of the potent pharmaceutical intermediates with three chiral centers. Here we report a metabolically engineered recombinant Bacillus megaterium strain with aroE (shikimate dehydrogenase)...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490670/ https://www.ncbi.nlm.nih.gov/pubmed/25981549 http://dx.doi.org/10.1186/s12934-015-0251-3 |