Detection of BCR-ABL T315I mutation by peptide nucleic acid directed PCR clamping and by peptide nucleic acid FISH

BACKGROUND: Mutations of the BCR-ABL1 fusion gene represent a well established cause of resistance to tyrosine kinase inhibitors. Among the different mutations identified T315I is of particular concern since it is not effectively targeted by the majority of Tyrosine Kinase Inhibitors so far availabl...

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Detalles Bibliográficos
Autores principales: Rosso, Valentina, Bracco, Enrico, Pedrola, Roberto, Carturan, Sonia, Signorino, Elisabetta, Petiti, Jessica, Calabrese, Chiara, Nicoli, Paolo, De Gobbi, Marco, Gaidano, Valentina, Gallo, Daniela, Ulisciani, Stefano, Fava, Carmen, Rege-Cambrin, Giovanna, Frassoni, Francesco, Saglio, Giuseppe, Cilloni, Daniela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Methodology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490729/
https://www.ncbi.nlm.nih.gov/pubmed/26146560
http://dx.doi.org/10.1186/s40364-015-0039-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490729/
https://www.ncbi.nlm.nih.gov/pubmed/26146560
http://dx.doi.org/10.1186/s40364-015-0039-y

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