Molecular basis for the inhibition of β-hydroxyacyl-ACP dehydratase HadAB complex from Mycobacterium tuberculosis by flavonoid inhibitors

Dehydration is one of the key steps in the biosynthesis of mycolic acids and is vital to the growth of Mycobacterium tuberculosis (Mtb). Consequently, stalling dehydration cures tuberculosis (TB). Clinically used anti-TB drugs like thiacetazone (TAC) and isoxyl (ISO) as well as flavonoids inhibit th...

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Detalles Bibliográficos
Autores principales: Dong, Yu, Qiu, Xiaodi, Shaw, Neil, Xu, Yueyang, Sun, Yuna, Li, Xuemei, Li, Jun, Rao, Zihe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Higher Education Press 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491049/
https://www.ncbi.nlm.nih.gov/pubmed/26081470
http://dx.doi.org/10.1007/s13238-015-0181-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491049/
https://www.ncbi.nlm.nih.gov/pubmed/26081470
http://dx.doi.org/10.1007/s13238-015-0181-1

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