Cargando…

Molecular basis for the inhibition of β-hydroxyacyl-ACP dehydratase HadAB complex from Mycobacterium tuberculosis by flavonoid inhibitors

Dehydration is one of the key steps in the biosynthesis of mycolic acids and is vital to the growth of Mycobacterium tuberculosis (Mtb). Consequently, stalling dehydration cures tuberculosis (TB). Clinically used anti-TB drugs like thiacetazone (TAC) and isoxyl (ISO) as well as flavonoids inhibit th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dong, Yu, Qiu, Xiaodi, Shaw, Neil, Xu, Yueyang, Sun, Yuna, Li, Xuemei, Li, Jun, Rao, Zihe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Higher Education Press 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491049/ https://www.ncbi.nlm.nih.gov/pubmed/26081470 http://dx.doi.org/10.1007/s13238-015-0181-1

Ejemplares similares

1,3-Diarylpyrazolyl-acylsulfonamides Target HadAB/BC Complex in Mycobacterium tuberculosis
por: Singh, Vinayak, et al.
Publicado: (2022)

Identification and Phenotypic Characterization of ZEBRA LEAF16 Encoding a β-Hydroxyacyl-ACP Dehydratase in Rice
por: Liu, Ziwen, et al.
Publicado: (2018)

Structures of an unusual 3-hydroxyacyl dehydratase (FabZ) from a ladderane-producing organism with an unexpected substrate preference
por: Dietl, Andreas, et al.
Publicado: (2023)

Emodin targets the β-hydroxyacyl-acyl carrier protein dehydratase from Helicobacter pylori: enzymatic inhibition assay with crystal structural and thermodynamic characterization
por: Chen, Jing, et al.
Publicado: (2009)

Cloning of the pks3 gene of Aurantiochytrium limacinum and functional study of the 3-ketoacyl-ACP reductase and dehydratase enzyme domains
por: Liu, Zhu, et al.
Publicado: (2018)

Crystal structure of FabZ-ACP complex reveals a dynamic seesaw-like catalytic mechanism of dehydratase in fatty acid biosynthesis
por: Zhang, Lin, et al.
Publicado: (2016)

Covalent Modification of the Mycobacterium tuberculosis FAS-II Dehydratase by Isoxyl and Thiacetazone
por: Grzegorzewicz, Anna E., et al.
Publicado: (2014)

Molecular Evolution of Threonine Dehydratase in Bacteria
por: Yu, Xuefei, et al.
Publicado: (2013)

The Mycobacterium Tuberculosis FAS-II Dehydratases and Methyltransferases Define the Specificity of the Mycolic Acid Elongation Complexes
por: Cantaloube, Sylvain, et al.
Publicado: (2011)

ACP basic statistics = ACP, statistiques de base.
Publicado: (1985)

Leptospiral 3-hydroxyacyl-CoA dehydrogenase as an early urinary biomarker of leptospirosis
por: Toma, Claudia, et al.
Publicado: (2018)

Discovery of Function in the Enolase Superfamily: d-Mannonate and d-Gluconate Dehydratases in the d-Mannonate Dehydratase Subgroup
por: Wichelecki, Daniel J., et al.
Publicado: (2014)

Dimerization Interface of 3-Hydroxyacyl-CoA Dehydrogenase Tunes the Formation of Its Catalytic Intermediate
por: Xu, Yingzhi, et al.
Publicado: (2014)

The crystal structure of D-xylonate dehydratase reveals functional features of enzymes from the Ilv/ED dehydratase family
por: Rahman, Mohammad Mubinur, et al.
Publicado: (2018)

GCNCPR-ACPs: a novel graph convolution network method for ACPs prediction
por: Wu, Xiujin, et al.
Publicado: (2022)

Identification of leptospiral 3-hydroxyacyl-CoA dehydrogenase released in the urine of infected hamsters
por: Segawa, Takaya, et al.
Publicado: (2014)

Peroxisomal 2-Hydroxyacyl-CoA Lyase Is Involved in Endogenous Biosynthesis of Heptadecanoic Acid
por: Jenkins, Benjamin, et al.
Publicado: (2017)

The Role of ACT-Like Subdomain in Bacterial Threonine Dehydratases
por: Yu, Xuefei, et al.
Publicado: (2014)

DLFF-ACP: prediction of ACPs based on deep learning and multi-view features fusion
por: Cao, Ruifen, et al.
Publicado: (2021)

Shewanella oneidensis FabB: A β-ketoacyl-ACP Synthase That Works with C16:1-ACP
por: Luo, Qixia, et al.
Publicado: (2016)

ACP medicine : a publication of the American College of Physicians /
Publicado: (2004)

Molecular characterization and immune protection of the 3-hydroxyacyl-CoA dehydrogenase gene in Echinococcus granulosus
por: Xian, Jinwen, et al.
Publicado: (2021)

Genetic pathogenesis, diagnosis, and treatment of short-chain 3-hydroxyacyl-coenzyme A dehydrogenase hyperinsulinism
por: Zhang, Wei, et al.
Publicado: (2021)

Management of pregnancy in a patient with long‐chain 3‐hydroxyacyl CoA dehydrogenase deficiency
por: Shakerdi, Loai A., et al.
Publicado: (2022)

A Structural and Energetic Model for the Slow-Onset Inhibition of the Mycobacterium tuberculosis Enoyl-ACP Reductase InhA
por: Li, Huei-Jiun, et al.
Publicado: (2014)

The Interactions of CPP–ACP with Saliva
por: Huq, Noorjahan Laila, et al.
Publicado: (2016)

Role of Serine140 in the mode of action of Mycobacterium tuberculosis β-ketoacyl-ACP Reductase (MabA)
por: Rosado, Leonardo A, et al.
Publicado: (2012)

Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta gene as a tumour suppressor in stomach adenocarcinoma
por: Li, Yun, et al.
Publicado: (2022)

Leucine-sensitive hyperinsulinaemic hypoglycaemia in patients with loss of function mutations in 3-Hydroxyacyl-CoA Dehydrogenase
por: Heslegrave, Amanda J, et al.
Publicado: (2012)

The Hypoglycemic Phenotype Is Islet Cell–Autonomous in Short-Chain Hydroxyacyl-CoA Dehydrogenase–Deficient Mice
por: Molven, Anders, et al.
Publicado: (2016)

Enoyl-CoA hydratase/3-hydroxyacyl CoA dehydrogenase is essential for the production of DHA in zebrafish
por: Yang, Gang, et al.
Publicado: (2022)

Discovery of Selective Inhibitors of the Clostridium difficile Dehydroquinate Dehydratase
por: Ratia, Kiira, et al.
Publicado: (2014)

Discovery of a novel dehydratase of the fatty acid synthase type II critical for ketomycolic acid biosynthesis and virulence of Mycobacterium tuberculosis
por: Lefebvre, Cyril, et al.
Publicado: (2020)

Cryo-EM structures for the Mycobacterium tuberculosis iron-loaded siderophore transporter IrtAB
por: Sun, Shan, et al.
Publicado: (2022)

ACP Conference on Fundamental Physics of Ferroelectrics
por: Cohen, Ronald E
Publicado: (2000)

Maryland ACP Winning Abstracts 2017
Publicado: (2017)

Intraarticular ACP therapy for severe osteoarthritis
por: Borsky, Michael
Publicado: (2019)

Short-chain L-3-hydroxyacyl-CoA dehydrogenase: A novel vital oncogene or tumor suppressor gene in cancers
por: Fang, He, et al.
Publicado: (2022)

The Non-Essential Mycolic Acid Biosynthesis Genes hadA and hadC Contribute to the Physiology and Fitness of Mycobacterium smegmatis
por: Jamet, Stevie, et al.
Publicado: (2015)

Cryo-EM snapshots of mycobacterial arabinosyltransferase complex EmbB(2)-AcpM(2)
por: Zhang, Lu, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_sjila237hpu536jmd9lm5qk210