Eliminate mitochondrial diseases by gene editing in germ-line cells and embryos

Nuclease-based gene editing technologies have opened up opportunities for correcting human genetic diseases. For the first time, scientists achieved targeted gene editing of mitochondrial DNA in mouse oocytes fused with patient cells. This fascinating progression may encourage the development of nov...

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Detalles Bibliográficos
Autores principales: Wang, Si, Yi, Fei, Qu, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Higher Education Press 2015
Materias:
Research Highlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491053/
https://www.ncbi.nlm.nih.gov/pubmed/26081469
http://dx.doi.org/10.1007/s13238-015-0177-x
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author Wang, Si
Yi, Fei
Qu, Jing
author_facet Wang, Si
Yi, Fei
Qu, Jing
author_sort Wang, Si
collection PubMed
description Nuclease-based gene editing technologies have opened up opportunities for correcting human genetic diseases. For the first time, scientists achieved targeted gene editing of mitochondrial DNA in mouse oocytes fused with patient cells. This fascinating progression may encourage the development of novel therapy for human maternally inherent mitochondrial diseases.
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spelling pubmed-44910532015-07-07 Eliminate mitochondrial diseases by gene editing in germ-line cells and embryos Wang, Si Yi, Fei Qu, Jing Protein Cell Research Highlight Nuclease-based gene editing technologies have opened up opportunities for correcting human genetic diseases. For the first time, scientists achieved targeted gene editing of mitochondrial DNA in mouse oocytes fused with patient cells. This fascinating progression may encourage the development of novel therapy for human maternally inherent mitochondrial diseases. Higher Education Press 2015-06-17 2015-07 /pmc/articles/PMC4491053/ /pubmed/26081469 http://dx.doi.org/10.1007/s13238-015-0177-x Text en © The Author(s) 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Research Highlight
Wang, Si
Yi, Fei
Qu, Jing
Eliminate mitochondrial diseases by gene editing in germ-line cells and embryos
title Eliminate mitochondrial diseases by gene editing in germ-line cells and embryos
title_full Eliminate mitochondrial diseases by gene editing in germ-line cells and embryos
title_fullStr Eliminate mitochondrial diseases by gene editing in germ-line cells and embryos
title_full_unstemmed Eliminate mitochondrial diseases by gene editing in germ-line cells and embryos
title_short Eliminate mitochondrial diseases by gene editing in germ-line cells and embryos
title_sort eliminate mitochondrial diseases by gene editing in germ-line cells and embryos
topic Research Highlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491053/
https://www.ncbi.nlm.nih.gov/pubmed/26081469
http://dx.doi.org/10.1007/s13238-015-0177-x
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AT yifei eliminatemitochondrialdiseasesbygeneeditingingermlinecellsandembryos
AT qujing eliminatemitochondrialdiseasesbygeneeditingingermlinecellsandembryos

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