Cargando…

Grb2 monomer–dimer equilibrium determines normal versus oncogenic function

The adaptor protein growth factor receptor-bound protein 2 (Grb2) is ubiquitously expressed in eukaryotic cells and involved in a multitude of intracellular protein interactions. Grb2 plays a pivotal role in tyrosine kinase-mediated signal transduction including linking receptor tyrosine kinases to...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ahmed, Zamal, Timsah, Zahra, Suen, Kin M., Cook, Nathan P., Lee, Gilbert R., Lin, Chi-Chuan, Gagea, Mihai, Marti, Angel A., Ladbury, John E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Pub. Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491180/ https://www.ncbi.nlm.nih.gov/pubmed/26103942 http://dx.doi.org/10.1038/ncomms8354

Ejemplares similares

Corrigendum: Grb2 monomer–dimer equilibrium determines normal versus oncogenic function
por: Ahmed, Zamal, et al.
Publicado: (2015)

Grb2 binding induces phosphorylation-independent activation of Shp2
por: Lin, Chi-Chuan, et al.
Publicado: (2021)

Regulation of microRNA expression by the adaptor protein GRB2
por: Stainthorp, Amy K., et al.
Publicado: (2023)

Grb2 controls phosphorylation of FGFR2 by inhibiting receptor kinase and Shp2 phosphatase activity
por: Ahmed, Zamal, et al.
Publicado: (2013)

Quantifying the Monomer–Dimer Equilibrium of Tubulin with Mass Photometry
por: Fineberg, Adam, et al.
Publicado: (2020)

Structural basis of the dynamic human CEACAM1 monomer-dimer equilibrium
por: Gandhi, Amit K., et al.
Publicado: (2021)

Full characterization of GPCR monomer–dimer dynamic equilibrium by single molecule imaging
por: Kasai, Rinshi S., et al.
Publicado: (2011)

FGF9 monomer/dimer equilibrium regulates extracellular matrix affinity and tissue diffusion
por: Harada, Masayo, et al.
Publicado: (2009)

Solvent Dependence of the Monomer–Dimer Equilibrium of Ketone‐Substituted Triscatecholate Titanium(IV) Complexes
por: Kwamen, A. Carel N., et al.
Publicado: (2020)

The Grb2 splice variant, Grb3-3, is a negative regulator of RAS activation
por: Seiler, Caroline, et al.
Publicado: (2022)

The combined action of the intracellular regions regulates FGFR2 kinase activity
por: Lin, Chi-Chuan, et al.
Publicado: (2023)

The dimer-monomer equilibrium of SARS-CoV-2 main protease is affected by small molecule inhibitors
por: Silvestrini, Lucia, et al.
Publicado: (2021)

Quantitative analysis of sterol-modulated monomer–dimer equilibrium of the β(1)-adrenergic receptor by DEER spectroscopy
por: Kubatova, Nina, et al.
Publicado: (2023)

Oncogenic Mutations Differentially Affect Bax Monomer, Dimer, and Oligomeric Pore Formation in the Membrane
por: Zhang, Mingzhen, et al.
Publicado: (2016)

Regulation of UVR8 photoreceptor dimer/monomer photo‐equilibrium in Arabidopsis plants grown under photoperiodic conditions
por: Findlay, Kirsten M.W., et al.
Publicado: (2016)

The crystal structure of the global anaerobic transcriptional regulator FNR explains its extremely fine-tuned monomer-dimer equilibrium
por: Volbeda, Anne, et al.
Publicado: (2015)

GRB7 is an oncogenic driver and potential therapeutic target in oesophageal adenocarcinoma
por: Gotovac, Jovana R, et al.
Publicado: (2020)

Dissecting Monomer-Dimer Equilibrium of an RNase P Protein Provides Insight Into the Synergistic Flexibility of 5’ Leader Pre-tRNA Recognition
por: Zeng, Danyun, et al.
Publicado: (2021)

Modulation of the monomer-dimer equilibrium and catalytic activity of SARS-CoV-2 main protease by a transition-state analog inhibitor
por: Nashed, Nashaat T., et al.
Publicado: (2022)

The Macronova in GRB 050709 and the GRB-macronova connection
por: Jin, Zhi-Ping, et al.
Publicado: (2016)

The monomer-dimer algorithm and QCD at finite density
por: Karsch, Frithjof
Publicado: (1990)

GRB10 is a novel oncogene associated with cell proliferation and prognosis in glioma
por: Chen, Yuanbing, et al.
Publicado: (2022)

Probing protein aggregation at buried interfaces: distinguishing between adsorbed protein monomers, dimers, and a monomer–dimer mixture in situ
por: Lu, Tieyi, et al.
Publicado: (2021)

Structural and functional properties of Grb2 SH2 dimer in CD28 binding
por: Hosoe, Yuhi, et al.
Publicado: (2019)

GRB2 enforces homology-directed repair initiation by MRE11
por: Ye, Zu, et al.
Publicado: (2021)

Mechanisms of Activation of Receptor Tyrosine Kinases: Monomers or Dimers
por: Maruyama, Ichiro N.
Publicado: (2014)

Anionic polycondensation and equilibrium driven monomer formation of cyclic aliphatic carbonates
por: Hua, Geng, et al.
Publicado: (2018)

A RET::GRB2 fusion in pheochromocytoma defies the classic paradigm of RET oncogenic fusions
por: Estrada-Zuniga, Cynthia M., et al.
Publicado: (2022)

Thermally Activated Delayed Fluorescence from d(10)‐Metal Carbene Complexes through Intermolecular Charge Transfer and Multicolor Emission with a Monomer–Dimer Equilibrium
por: Cao, Lei, et al.
Publicado: (2020)

GRB2 dimerization mediated by SH2 domain-swapping is critical for T cell signaling and cytokine production
por: Sandouk, Aline, et al.
Publicado: (2023)

Taking deterministic control of membrane protein monomer–dimer measurements
por: Fleming, Karen G.
Publicado: (2018)

The Reaction of Dimerization by Itself Reduces the Noise Intensity of the Protein Monomer
por: Liu, Feng-You, et al.
Publicado: (2019)

Interactome dynamics of RAF1-BRAF kinase monomers and dimers
por: Iglesias-Martinez, Luis F., et al.
Publicado: (2023)

Role of Monomer/Tetramer Equilibrium of Rod Visual Arrestin in the Interaction with Phosphorylated Rhodopsin
por: Imamoto, Yasushi, et al.
Publicado: (2023)

Dynamic tuneable G protein-coupled receptor monomer-dimer populations
por: Dijkman, Patricia M., et al.
Publicado: (2018)

Antimicrobial activity of resveratrol-derived monomers and dimers against foodborne pathogens
por: Mattio, Luce M., et al.
Publicado: (2019)

Structural insights into the BRAF monomer-to-dimer transition mediated by RAS binding
por: Martinez Fiesco, Juliana A., et al.
Publicado: (2022)

Plant‐Derived Stilbenoids as DNA‐Binding Agents: From Monomers to Dimers
por: Platella, Chiara, et al.
Publicado: (2021)

Unveiling the dimer/monomer propensities of Smad MH1-DNA complexes
por: Ruiz, Lidia, et al.
Publicado: (2021)

Healing effects of monomer and dimer resveratrol in a mouse periodontitis model
por: Ikeda, Eri, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_5gb24g07ub1c19u1m5krjqped3