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Midostaurin preferentially attenuates proliferation of triple-negative breast cancer cell lines through inhibition of Aurora kinase family

BACKGROUND: Breast cancer is classified into three subtypes by the expression of biomarker receptors such as hormone receptors and human epidermal growth factor receptor 2. Triple-negative breast cancer (TNBC) expresses none of these receptors and has an aggressive phenotype with a poor prognosis, w...

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Detalles Bibliográficos
Autores principales: Kawai, Masaaki, Nakashima, Akio, Kamada, Shinji, Kikkawa, Ushio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491224/
https://www.ncbi.nlm.nih.gov/pubmed/26141684
http://dx.doi.org/10.1186/s12929-015-0150-2