Methotrexate Associated Renal Impairment Is Related to Delayed Elimination of High-Dose Methotrexate

Although Methotrexate (MTX) is an effective drug for the treatment of acute lymphoblastic leukemia (ALL), the toxicity remains a significant problem. In this prospective study, fifty-four patients with ALL were enrolled. 3 g or 5 g MTX/m(2) was administered over 24 hours. Serum MTX concentrations we...

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Detalles Bibliográficos
Autores principales: Yang, Shi-Long, Zhao, Fen-Ying, Song, Hua, Shen, Di-Ying, Xu, Xiao-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Clinical Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491404/
https://www.ncbi.nlm.nih.gov/pubmed/26185782
http://dx.doi.org/10.1155/2015/751703

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491404/
https://www.ncbi.nlm.nih.gov/pubmed/26185782
http://dx.doi.org/10.1155/2015/751703

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