Metformin induces ER stress-dependent apoptosis through miR-708-5p/NNAT pathway in prostate cancer

Although the antitumor role of metformin has been widely reported, the molecular mechanism of this biguanide agent in the inhibition of tumor progression remains unclear. Here, we identified miR-708-5p as a novel target of metformin in prostate cancer cells. Metformin promotes increased expression o...

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Detalles Bibliográficos
Autores principales: Yang, J, Wei, J, Wu, Y, Wang, Z, Guo, Y, Lee, P, Li, X
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491613/
https://www.ncbi.nlm.nih.gov/pubmed/26075749
http://dx.doi.org/10.1038/oncsis.2015.18

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491613/
https://www.ncbi.nlm.nih.gov/pubmed/26075749
http://dx.doi.org/10.1038/oncsis.2015.18

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