Seatbelts in CAR therapy: How Safe Are CARS?

T-cells genetically redirected with a chimeric antigen receptor (CAR) to recognize tumor antigens and kill tumor cells have been infused in several phase 1 clinical trials with success. Due to safety concerns related to on-target/off-tumor effects or cytokine release syndrome, however, strategies to...

Descripción completa

Detalles Bibliográficos
Autores principales: Minagawa, Kentaro, Zhou, Xiaoou, Mineishi, Shin, Di Stasi, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491658/
https://www.ncbi.nlm.nih.gov/pubmed/26110321
http://dx.doi.org/10.3390/ph8020230

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491658/
https://www.ncbi.nlm.nih.gov/pubmed/26110321
http://dx.doi.org/10.3390/ph8020230

Ejemplares similares