The HSP90 Inhibitor Ganetespib Radiosensitizes Human Lung Adenocarcinoma Cells

The molecular chaperone HSP90 is involved in stabilization and function of multiple client proteins, many of which represent important oncogenic drivers in NSCLC. Utilization of HSP90 inhibitors as radiosensitizing agents is a promising approach. The antitumor activity of ganetespib, HSP90 inhibitor...

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Detalles Bibliográficos
Autores principales: Gomez-Casal, Roberto, Bhattacharya, Chitralekha, Epperly, Michael W., Basse, Per H., Wang, Hong, Wang, Xinhui, Proia, David A., Greenberger, Joel S., Socinski, Mark A., Levina, Vera
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491689/
https://www.ncbi.nlm.nih.gov/pubmed/26010604
http://dx.doi.org/10.3390/cancers7020814

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4491689/
https://www.ncbi.nlm.nih.gov/pubmed/26010604
http://dx.doi.org/10.3390/cancers7020814

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