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FTY720 inhibited proinflammatory cytokine release and osteoclastogenesis induced by Aggregatibacter actinomycetemcomitans
BACKGROUND: Periodontitis is a bacteria-driven inflammatory bone loss disease. Previous studies showed that the oral pathogen Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans) stimulated the generation of sphingosine 1 phosphate (S1P). In addition, S1P signaling regulated the migratio...
Autores principales: | Yu, Hong, Herbert, Bethany A., Valerio, Michael, Yarborough, Leigh, Hsu, Li-Chien, Argraves, Kelley M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492085/ https://www.ncbi.nlm.nih.gov/pubmed/26138336 http://dx.doi.org/10.1186/s12944-015-0057-7 |
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