Cargando…

Inhibition of Nuclear Receptor Binding SET Domain 2/Multiple Myeloma SET Domain by LEM-06 Implication for Epigenetic Cancer Therapies

BACKGROUND: Multiple myeloma SET domain (MMSET)/nuclear receptor binding SET domain 2 (NSD2) is a lysine histone methyltransferase (HMTase) and bona fide oncoprotein found aberrantly expressed in several cancers, suggesting potential role for novel therapeutic strategies. In particular, MMSET/NSD2 i...

Descripción completa

Detalles Bibliográficos
Autor principal:	di Luccio, Eric
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Korean Society of Cancer Prevention 2015
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492355/ https://www.ncbi.nlm.nih.gov/pubmed/26151044 http://dx.doi.org/10.15430/JCP.2015.20.2.113

Ejemplares similares

The nuclear envelope LEM-domain protein emerin
por: Berk, Jason M, et al.
Publicado: (2013)

LEM-3 – A LEM Domain Containing Nuclease Involved in the DNA Damage Response in C. elegans
por: Dittrich, Christina M., et al.
Publicado: (2012)

Heterogeneous Immunoreactivity of Emerin, a Nuclear Envelope LEM-domain Protein, in Normal Thyroid Follicles
por: Jieying, Wang, et al.
Publicado: (2014)

An Emerin LEM-Domain Mutation Impairs Cell Response to Mechanical Stress
por: Essawy, Nada, et al.
Publicado: (2019)

Collective analysis of the expression and prognosis for LEM-domain proteins in prostate cancer
por: He, Tianzhen, et al.
Publicado: (2022)

Nuclear medicine imaging of multiple myeloma, particularly in the relapsed setting
por: de Waal, Esther G. M., et al.
Publicado: (2016)

The immune checkpoint molecule V-set Ig domain-containing 4 is an independent prognostic factor for multiple myeloma
por: Roh, Jin, et al.
Publicado: (2017)

Transgenerational Epigenetic Inheritance Is Revealed as a Multi-step Process by Studies of the SET-Domain Proteins SET-25 and SET-32
por: Woodhouse, Rachel M, et al.
Publicado: (2019)

Elevated expression of nuclear receptor-binding SET domain 3 promotes pancreatic cancer cell growth
por: Sun, Yihui, et al.
Publicado: (2021)

Identification of the evolutionarily conserved nuclear envelope proteins Lem2 and MicLem2 in Tetrahymena thermophila
por: Iwamoto, Masaaki, et al.
Publicado: (2019)

Nucleo-cytoplasmic shuttling of the endonuclease ankyrin repeats and LEM domain-containing protein 1 (Ankle1) is mediated by canonical nuclear export- and nuclear import signals
por: Zlopasa, Livija, et al.
Publicado: (2016)

LEM domain containing 1 promotes oral squamous cell carcinoma invasion and endothelial transmigration
por: Sasahira, Tomonori, et al.
Publicado: (2016)

Identifying Small‐Molecule Binding Sites for Epigenetic Proteins at Domain–Domain Interfaces
por: Bowkett, David, et al.
Publicado: (2018)

Phylogenetic relationship and domain organisation of SET domain proteins of Archaeplastida
por: Sarma, Supriya, et al.
Publicado: (2017)

Lem2 is essential for cardiac development by maintaining nuclear integrity
por: Ross, Jacob A, et al.
Publicado: (2023)

NSD3, a member of nuclear receptor‐binding SET domain family, is a potential prognostic biomarker for pancreatic cancer
por: Xiong, Qunli, et al.
Publicado: (2023)

LEM Domain Containing 1 Acts as a Novel Oncogene and Therapeutic Target for Triple-Negative Breast Cancer
por: Li, Xiangling, et al.
Publicado: (2023)

Nuclear membrane protein Lem2 regulates nuclear size through membrane flow
por: Kume, Kazunori, et al.
Publicado: (2019)

The inner nuclear membrane protein Lem2 coordinates RNA degradation at the nuclear periphery
por: Martín Caballero, Lucía, et al.
Publicado: (2022)

Control of heterochromatin localization and silencing by the nuclear membrane protein Lem2
por: Barrales, Ramón Ramos, et al.
Publicado: (2016)

Loss of nuclear envelope integrity? No probLEM—BAF has it covered
por: King, Megan C., et al.
Publicado: (2019)

Stationary sets for the wave equation in chrystallographic domains
por: Agranovsky, M L, et al.
Publicado: (2002)

Kinase domain activation through gene rearrangement in multiple myeloma
por: Morgan, Gareth J, et al.
Publicado: (2018)

The Trithorax group protein ASH1 requires a combination of BAH domain and AT hooks, but not the SET domain, for mitotic chromatin binding and survival
por: Steffen, Philipp A., et al.
Publicado: (2021)

Chromatin binding and silencing: Two roles of the same protein Lem2
por: Barrales, Ramón Ramos, et al.
Publicado: (2016)

LEM2 phase separation governs ESCRT-mediated nuclear envelope reformation
por: von Appen, Alexander, et al.
Publicado: (2020)

The GIY-YIG Type Endonuclease Ankyrin Repeat and LEM Domain-Containing Protein 1 (ANKLE1) Is Dispensable for Mouse Hematopoiesis
por: Braun, Juliane, et al.
Publicado: (2016)

LEM domain containing 1 promotes pancreatic cancer growth and metastasis by p53 and mTORC1 signaling pathway
por: Cao, Xiang, et al.
Publicado: (2022)

A crucial RNA-binding lysine residue in the Nab3 RRM domain undergoes SET1 and SET3-responsive methylation
por: Lee, Kwan Yin, et al.
Publicado: (2020)

Epigenetic Aberrations in Multiple Myeloma
por: Caprio, Cinzia, et al.
Publicado: (2020)

The SET-domain protein superfamily: protein lysine methyltransferases
por: Dillon, Shane C, et al.
Publicado: (2005)

Structural Chemistry of Human SET Domain Protein Methyltransferases
por: Schapira, Matthieu
Publicado: (2011)

The Unique Range Set of Meromorphic Functions in an Angular Domain
por: Xu, Hong-Yan, et al.
Publicado: (2014)

Structure and Function of SET and MYND Domain-Containing Proteins
por: Spellmon, Nicholas, et al.
Publicado: (2015)

Evolving Catalytic Properties of the MLL Family SET Domain
por: Zhang, Ying, et al.
Publicado: (2015)

A set of domain-specific markers in the Arabidopsis embryo
por: Wendrich, Jos R., et al.
Publicado: (2015)

SET Domain Containing 2 Deficiency in Myelodysplastic Syndrome
por: Li, Jiaming, et al.
Publicado: (2020)

Unmasking the mammalian SET domain-containing protein 4
por: Wang, Yuan, et al.
Publicado: (2022)

SET and MYND domain-containing protein 3 inhibits tumor cell sensitivity to cisplatin
por: Wang, Lei, et al.
Publicado: (2020)

Smith-Lemli-Opitz-syndrome
por: Gedam, Rachana, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_14e1vmpil059bl569hst9t50i1