In vivo Modeling Implicates APOL1 in Nephropathy: Evidence for Dominant Negative Effects and Epistasis under Anemic Stress

African Americans have a disproportionate risk for developing nephropathy. This disparity has been attributed to coding variants (G1 and G2) in apolipoprotein L1 (APOL1); however, there is little functional evidence supporting the role of this protein in renal function. Here, we combined genetics an...

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Detalles Bibliográficos
Autores principales: Anderson, Blair R., Howell, David N., Soldano, Karen, Garrett, Melanie E., Katsanis, Nicholas, Telen, Marilyn J., Davis, Erica E., Ashley-Koch, Allison E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492502/
https://www.ncbi.nlm.nih.gov/pubmed/26147622
http://dx.doi.org/10.1371/journal.pgen.1005349

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492502/
https://www.ncbi.nlm.nih.gov/pubmed/26147622
http://dx.doi.org/10.1371/journal.pgen.1005349

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