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Production of Cloned Miniature Pigs Expressing High Levels of Human Apolipoprotein(a) in Plasma
High lipoprotein(a) [Lp(a)] levels are a major risk factor for the development of atherosclerosis. However, because apolipoprotein(a) [apo(a)], the unique component of Lp(a), is found only in primates and humans, the study of human Lp(a) has been hampered due to the lack of appropriate animal models...
Autores principales: | Ozawa, Masayuki, Himaki, Takehiro, Ookutsu, Shoji, Mizobe, Yamato, Ogawa, Junki, Miyoshi, Kazuchika, Yabuki, Akira, Fan, Jianglin, Yoshida, Mitsutoshi |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492603/ https://www.ncbi.nlm.nih.gov/pubmed/26147378 http://dx.doi.org/10.1371/journal.pone.0132155 |
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