CO-Releasing Molecules Have Nonheme Targets in Bacteria: Transcriptomic, Mathematical Modeling and Biochemical Analyses of CORM-3 [Ru(CO)(3)Cl(glycinate)] Actions on a Heme-Deficient Mutant of Escherichia coli

Aims: Carbon monoxide-releasing molecules (CORMs) are being developed with the ultimate goal of safely utilizing the therapeutic potential of CO clinically, including applications in antimicrobial therapy. Hemes are generally considered the prime targets of CO and CORMs, so we tested this hypothesis...

Descripción completa

Detalles Bibliográficos
Autores principales: Wilson, Jayne Louise, Wareham, Lauren K., McLean, Samantha, Begg, Ronald, Greaves, Sarah, Mann, Brian E., Sanguinetti, Guido, Poole, Robert K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc. 2015
Materias:
Original Research Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492677/
https://www.ncbi.nlm.nih.gov/pubmed/25811604
http://dx.doi.org/10.1089/ars.2014.6151

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492677/
https://www.ncbi.nlm.nih.gov/pubmed/25811604
http://dx.doi.org/10.1089/ars.2014.6151

Ejemplares similares