Cargando…

CO-Releasing Molecules Have Nonheme Targets in Bacteria: Transcriptomic, Mathematical Modeling and Biochemical Analyses of CORM-3 [Ru(CO)(3)Cl(glycinate)] Actions on a Heme-Deficient Mutant of Escherichia coli

Aims: Carbon monoxide-releasing molecules (CORMs) are being developed with the ultimate goal of safely utilizing the therapeutic potential of CO clinically, including applications in antimicrobial therapy. Hemes are generally considered the prime targets of CO and CORMs, so we tested this hypothesis...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wilson, Jayne Louise, Wareham, Lauren K., McLean, Samantha, Begg, Ronald, Greaves, Sarah, Mann, Brian E., Sanguinetti, Guido, Poole, Robert K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Mary Ann Liebert, Inc. 2015
Materias:	Original Research Communications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492677/ https://www.ncbi.nlm.nih.gov/pubmed/25811604 http://dx.doi.org/10.1089/ars.2014.6151

Ejemplares similares

Analysis of transcript changes in a heme-deficient mutant of Escherichia coli in response to CORM-3 [Ru(CO)(3)Cl(glycinate)]
por: Wilson, Jayne Louise, et al.
Publicado: (2015)

The Broad-Spectrum Antimicrobial Potential of [Mn(CO)(4)(S(2)CNMe(CH(2)CO(2)H))], a Water-Soluble CO-Releasing Molecule (CORM-401): Intracellular Accumulation, Transcriptomic and Statistical Analyses, and Membrane Polarization
por: Wareham, Lauren K., et al.
Publicado: (2018)

CORM-3 induces DNA damage through Ru(II) binding to DNA
por: Lyon, Rhiannon F., et al.
Publicado: (2022)

Mechanisms of catalytic reduction of CO(2) with heme and nonheme metal complexes
por: Fukuzumi, Shunichi, et al.
Publicado: (2018)

Sensing a CO-Releasing Molecule (CORM) Does Not Equate to Sensing CO: The Case of DPHP and CORM-3
por: Liu, Dongning, et al.
Publicado: (2023)

Cytochrome bd-I in Escherichia coli is less sensitive than cytochromes bd-II or bo′' to inhibition by the carbon monoxide-releasing molecule, CORM-3()(): N-acetylcysteine reduces CO-RM uptake and inhibition of respiration
por: Jesse, Helen E., et al.
Publicado: (2013)

Alkene Cleavage Catalysed by Heme and Nonheme Enzymes: Reaction Mechanisms and Biocatalytic Applications
por: Mutti, Francesco G.
Publicado: (2012)

Gestational Diabetes Mellitus in Relation to Maternal Dietary Heme Iron and Nonheme Iron Intake
por: Qiu, Chunfang, et al.
Publicado: (2011)

Heme and Nonheme High-Valent Iron and Manganese Oxo Cores in Biological and Abiological Oxidation Reactions
por: Guo, Mian, et al.
Publicado: (2018)

Analysis of Environmental Determinants of Heme and Nonheme Iron Intake in a National Sample of Polish Adolescents
por: Skolmowska, Dominika, et al.
Publicado: (2021)

Direct Measurement of the Visible to UV Photodissociation Processes for the PhotoCORM TryptoCORM
por: Cercola, Rosaria, et al.
Publicado: (2020)

Proximate ferromagnetic state in the Kitaev model material α-RuCl(3)
por: Suzuki, H., et al.
Publicado: (2021)

Ru(phen)(3)Cl(2)‐Catalyzed Chlorotrifluoromethylation of Unactivated Alkenes
por: Su, Wenhao, et al.
Publicado: (2023)

Formation of high molecular weight p62 by CORM-3
por: Aki, Toshihiko, et al.
Publicado: (2019)

‘Carbon-Monoxide-Releasing Molecule-2 (CORM-2)’ Is a Misnomer: Ruthenium Toxicity, Not CO Release, Accounts for Its Antimicrobial Effects
por: Southam, Hannah M., et al.
Publicado: (2021)

Unexpected effect of catalyst concentration on photochemical CO(2) reduction by trans(Cl)–Ru(bpy)(CO)(2)Cl(2): new mechanistic insight into the CO/HCOO(–) selectivity
por: Kuramochi, Yusuke, et al.
Publicado: (2015)

CO-Releasing Molecule (CORM)-3 Ameliorates Spinal Cord-Blood Barrier Disruption Following Injury to the Spinal Cord
por: Zheng, Gang, et al.
Publicado: (2020)

Charge-Transfer Plasmon Polaritons at Graphene/α-RuCl(3) Interfaces
por: Rizzo, Daniel J., et al.
Publicado: (2020)

The Protective Role of Carbon Monoxide (CO) Produced by Heme Oxygenases and Derived from the CO-Releasing Molecule CORM-2 in the Pathogenesis of Stress-Induced Gastric Lesions: Evidence for Non-Involvement of Nitric Oxide (NO)
por: Magierowska, Katarzyna, et al.
Publicado: (2016)

Nanostructured RuO(2)–Co(3)O(4)@RuCo-EO with low Ru loading as a high-efficiency electrochemical oxygen evolution catalyst
por: Tan, Lingjun, et al.
Publicado: (2021)

Carbon Monoxide Gas Is Not Inert, but Global, in Its Consequences for Bacterial Gene Expression, Iron Acquisition, and Antibiotic Resistance
por: Wareham, Lauren K., et al.
Publicado: (2016)

Ultrafast Spin Dynamics and Photoinduced Insulator-to-Metal Transition in α-RuCl(3)
por: Zhang, Jin, et al.
Publicado: (2023)

CO-releasing molecules (CORM-2)-liberated CO attenuates leukocytes infiltration in the renal tissue of thermally injured mice
por: Sun, Bingwei, et al.
Publicado: (2008)

Carbon monoxide releasing molecule-2 (CORM-2)-liberated CO ameliorates acute pancreatitis
por: Liu, Yishu, et al.
Publicado: (2019)

A thiol-reactive Ru(II) ion, not CO release, underlies the potent antimicrobial and cytotoxic properties of CO-releasing molecule-3
por: Southam, Hannah M., et al.
Publicado: (2018)

Efficient NH(3)-based process to remove chlorine from electron beam deposited ruthenium produced from (η(3)-C(3)H(5))Ru(CO)(3)Cl
por: Rohdenburg, Markus, et al.
Publicado: (2020)

Stepwise nitrosylation of the nonheme iron site in an engineered azurin and a molecular basis for nitric oxide signaling mediated by nonheme iron proteins
por: Tian, Shiliang, et al.
Publicado: (2021)

Identification and Spectroscopic Characterization of Nonheme Iron(III) Hypochlorite Intermediates**
por: Draksharapu, Apparao, et al.
Publicado: (2015)

Identification and Spectroscopic Characterization of Nonheme Iron(III) Hypochlorite Intermediates
por: Draksharapu, Apparao, et al.
Publicado: (2015)

Characterization of a Paramagnetic Mononuclear Nonheme Iron-Superoxo Complex
por: Chiang, Chien-Wei, et al.
Publicado: (2014)

Atomic-scale observation of structural and electronic orders in the layered compound α-RuCl(3)
por: Ziatdinov, M., et al.
Publicado: (2016)

Giant phonon anomalies in the proximate Kitaev quantum spin liquid α-RuCl(3)
por: Li, Haoxiang, et al.
Publicado: (2021)

Identification of magnetic interactions and high-field quantum spin liquid in α-RuCl(3)
por: Li, Han, et al.
Publicado: (2021)

Nanometer-Scale Lateral p–n Junctions in Graphene/α-RuCl(3) Heterostructures
por: Rizzo, Daniel J., et al.
Publicado: (2022)

Differential Effects of CORM-2 and CORM-401 in Murine Intestinal Epithelial MODE-K Cells under Oxidative Stress
por: Babu, Dinesh, et al.
Publicado: (2017)

Structural Analysis of an Open Active Site Conformation of Nonheme Iron Halogenase CytC3
por: Wong, Cintyu, et al.
Publicado: (2009)

ItaCORMs: conjugation with a CO-releasing unit greatly enhances the anti-inflammatory activity of itaconates
por: Krause, Bernhard M., et al.
Publicado: (2021)

The Production of Nitrous Oxide by the Heme/Nonheme Diiron Center of Engineered Myoglobins (Fe(B)Mbs) Proceeds through a trans-Iron-Nitrosyl Dimer
por: Matsumura, Hirotoshi, et al.
Publicado: (2014)

Heme, Heme Oxygenase-1, Statins, and SARS-CoV-2
por: Stevenson, David K., et al.
Publicado: (2023)

The interaction of size-selected Ru(3) clusters with RF-deposited TiO(2): probing Ru–CO binding sites with CO-temperature programmed desorption
por: Howard-Fabretto, Liam, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_1dr4m7uf63dd13e8nfmqq7l85p