CDK5 Regulates Paclitaxel Sensitivity in Ovarian Cancer Cells by Modulating AKT Activation, p21Cip1- and p27Kip1-Mediated G1 Cell Cycle Arrest and Apoptosis

Cyclin-dependent kinase 5 (CDK5) is a cytoplasmic serine/ threonine kinase. Knockdown of CDK5 enhances paclitaxel sensitivity in human ovarian cancer cells. This study explores the mechanisms by which CDK5 regulates paclitaxel sensitivity in human ovarian cancers. Multiple ovarian cancer cell lines...

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Detalles Bibliográficos
Autores principales: Zhang, Shu, Lu, Zhen, Mao, Weiqun, Ahmed, Ahmed A., Yang, Hailing, Zhou, Jinhua, Jennings, Nicholas, Rodriguez-Aguayo, Cristian, Lopez-Berestein, Gabriel, Miranda, Roberto, Qiao, Wei, Baladandayuthapani, Veera, Li, Zongfang, Sood, Anil K., Liu, Jinsong, Le, Xiao-Feng, Bast, Robert C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492679/
https://www.ncbi.nlm.nih.gov/pubmed/26146988
http://dx.doi.org/10.1371/journal.pone.0131833

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492679/
https://www.ncbi.nlm.nih.gov/pubmed/26146988
http://dx.doi.org/10.1371/journal.pone.0131833

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