The putative P-gp inhibitor telmisartan does not affect the transcellular permeability and cellular uptake of the calcium channel antagonist verapamil in the P-glycoprotein expressing cell line MDCK II MDR1

Verapamil is used in high doses for the treatment of cluster headache. Verapamil has been described as a P-glycoprotein (P-gp, ABCB1) substrate. We wished to evaluate in vitro whether co administration of a P-gp inhibitor with verapamil could be a feasible strategy for increasing CNS uptake of verap...

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Detalles Bibliográficos
Autores principales: Saaby, Lasse, Tfelt-Hansen, Peer, Brodin, Birger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2015
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492727/
https://www.ncbi.nlm.nih.gov/pubmed/26171231
http://dx.doi.org/10.1002/prp2.151

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492727/
https://www.ncbi.nlm.nih.gov/pubmed/26171231
http://dx.doi.org/10.1002/prp2.151

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